Senior Scientist (Oligonucleotide Therapeutics)

Company: Regeneron Pharmaceuticals, Inc.
Location: Tarrytown
Posted on: January 13, 2026

Job Description:

We are seeking a curious and motivated Senior Scientist to join our Regeneron Genetic Medicines group, working on oligonucleotide-based therapeutics. You will be spearheading assay development, candidate screening, validation, and structure-activity relationship (SAR) optimization. The role involves siRNA design, high-throughput screening (HTS), off-target analysis, and molecule optimization to support therapeutic development. As a Senior Scientist, a typical day might include: siRNA Design & Screening: Design and optimize siRNAs for target specificity and efficacy. Lead high-throughput screening (HTS) and secondary screening, including dose-response studies to determine IC50. Assay Development & Validation: Develop and validate screening assays (e.g., bDNA, RT-qPCR). Implement automation for HTS and optimize screening systems (e.g., primary cells, reporter systems). Off-Target Analysis & SAR Optimization: Establish off-target screening approaches. Use off-target data to guide SAR optimization and improve molecular design. Team Leadership & Collaboration: Lead a multidisciplinary team, ensuring alignment with project goals. Collaborate with bioinformatics, automation, and chemistry teams. This Role Could Be a Great Fit If You: Are passionate about siRNA therapeutics and thrive on translating cutting-edge research discoveries into impactful therapeutic candidates. Hold strong attention to detail, maintain a rigorous approach to scientific work, and communicate effectively with colleagues across all levels, from junior team members to senior leadership. Enjoy working in a dynamic, fast-paced team environment, excel at collaboration, and can adapt to shifting priorities comfortably. Are eager to grow your career in the oligonucleotide therapeutics field, with opportunities to contribute to programs spanning the discovery phase through clinical development. In order to be considered for this role, you must have : Ph.D. in Molecular Biology, Biochemistry, or related field. 3 years of experience in RNAi research, high throughput screening, and/or SAR optimization. Expertise in siRNA design, assay development, and off-target analysis. Proficiency in RT-qPCR, including probe designs and multiplex assay development. Experience with primary cells and reporter systems. Experience with automation systems and bDNA assays to support HTS Knowledge of computational tools for transcriptome analysis. Background in drug discovery workflows. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regenerons roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regenerons on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $108,300.00 - $176,700.00

Keywords: Regeneron Pharmaceuticals, Inc., White Plains , Senior Scientist (Oligonucleotide Therapeutics), Science, Research & Development , Tarrytown, New York